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In a 2015 trial, oral tofacitinib was superior to placebo and as safe and effective as etanercept, one of the most widely used injectable biologics, for the treatment of moderate-to-severe plaque psoriasis

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The technique is simple, but each step matters for consistent absorption and minimal discomfort

Moreover, the apparent inevitability of stigma for GLP-1 users is concerning, particularly given that a desire to escape weight stigma has been conceptualized as a driver of unhealthy weight control behaviors (e.g., purging, skipping meals) and social isolation [48, 49]