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NNMT knockdown in WAT and liver protects against diet-induced obesity by augmenting cellular energy expenditure

Researchers have extensively studied NNMT due to observations linking elevated NNMT activity with changes in adipose tissue biology, metabolic efficiency, and energy regulation

When dosed 46 hours apart, the compounds avoid competitive binding while maximising fat oxidation, energy expenditure, and mitochondrial efficiencydelivering outcomes neither achieves at full capacity alone