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One of those dual agonists, tirzepatide (Mounjaro/Zepbound, Eli Lilly), was associated with a mean 14.7% weight loss for adults with overweight or obesity and type 2 diabetes in the SURMOUNT-2 trial compared with a 3.2% weight loss with placebo

On the other hand, vitamin B6 is found in meat, dairy products, nuts, fruits and vegetables [109], and vitamin B12 in meat, milk, eggs and fish [108]

For instance, compound 6o was found to dose-dependently suppress lipopolysaccharide-induced TNF- generation in both in vivo and in vitro models, and the inhibition percentage of TNF- by compound 6o (100 mg/kg) in vivo reached 54.7%

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