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All four rows describe patients with type 2 diabetes at high cardiovascular risk, namely LEADER, SUSTAIN-6, PIONEER 6, and REWIND, with the REWIND row also noting reduced major adverse cardiac events

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However, emerging evidence supports a role for Rab7, a small GTPase and important regulator of endocytic trafficking, in LD-lysosome MCS formation in hepatocytes (Schroeder et al., 2015)