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The neuronal lineage commitment of NPCs, their exit from the cell cycle and further neuronal maturation is initiated by TFs of the basic helix-loop-helix (bHLH) family: Ngn2, NeuroD1 and NeuroD2 (Pleasure et al., 2000

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The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations

On the other hand, in case of excessive distress, cells are exposed to high levels of ROS which can cause neuroinflammation, damage to the blood-brain barrier (BBB) and impairment to astrocyte crosstalk leading to ASD (El-Ansary et al., 2018