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When it comes to chronic, generalized pain that affects the whole body, the differential diagnosis might include: People who develop increased sensitivity to pain due to prolonged use of opioids Patients with depression, other mental health disorders or sleep issues like insomnia Autoimmune diseases (like lupus or psoriatic arthritis) Fibromyalgia Central pain syndromes Moreover, there are main four kinds of pain: caused by nerve damage (neuropathic), related to the muscles or skeleton (musculoskeletal), due to physical forces (mechanical), and related to inflammation

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COX7A1 also inhibits PINK1/Parkin and PGC-1 expression, hinders autophagic flux and mitophagy activation, and mediates ferroptosis in NSCLC, which can be promoted by high levels of Fe 2+ [200]

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