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These make zero-calorie sweeteners harder to incorporate into certain foods, limiting their adoption

Other genetic factors including variants in the FTO gene (rs9939609), which predisposes to obesity, and the MC4R gene (rs17782313), involved in appetite regulation, may provide context for understanding baseline metabolic function

Together these data indicate that although vagal afferent neurons may contribute to hypophagia induced by peripheral administration of GLP-1R analogs, these neurons are not necessary for the hypophagic effect

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