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Unintentional weight loss exceeding clinical targets, inability to maintain adequate nutrition or hydration, or new or worsening heartburn or reflux symptoms that don't respond to over-the-counter treatments also warrant medical consultation

Follistatin-344 sequesters myostatin extracellularly before ActRIIB engagement: 1:2 follistatin:myostatin stoichiometry (two myostatin monomers cradled per follistatin molecule)

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Manufacturing and formulation challenges continue to be addressed through technological advances and improved understanding of peptide properties