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Gastrointestinal adverse events including nausea, vomiting, and diarrhea are common with current GLP-1 agonists, leading some patients to discontinue treatment or fail to reach maximally effective doses

The olezarsen 50 mg dose did not result in a significant reduction in fasting TG levels from baseline compared to placebo at six months (LS mean difference, -22.4 percentage points

GLP-1 receptor agonists seem to have the unique ability to reduce these effects without completely blocking dopamine release

First, concentration scales with vial content at fixed fill volume, so a 20mg vial reconstituted with a volume carried over from 10mg work yields double the intended concentration