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The emphasis remains on risk mitigation, clinical accountability, and alignment with established treatment standards

Patients should contact their GP or diabetes specialist nurse if they experience: New onset or worsening erectile dysfunction after starting tirzepatide Sexual dysfunction accompanied by other concerning symptoms such as chest pain, breathlessness, or leg pain (which may indicate cardiovascular disease) Psychological distress related to sexual function affecting quality of life or relationships Concerns about whether tirzepatide or other medications may be contributing to symptoms During consultation, healthcare professionals will typically conduct a comprehensive assessment including medical history, medication review, cardiovascular risk evaluation, and consideration of psychological factors

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This interaction stimulates ghrelin receptors in the brain, leading to an increase in growth hormone release