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However, pharmacodynamic interactions where the combined effects of two drugs influence the same physiological outcomes are a more relevant concern

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This is based on observations of excessive apoptosis of T and B lymphocytes and on defective clearance of apoptotic cells in patients with SLE [4,101]

This was supported in 5xFAD mice, in which exendin-4 treatment alleviated cognitive dysfunction, prevented amyloid- accumulation, and protected mitochondrial function [54]