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Following, MD simulation of all the docked flavonoids with mh-Tyr also exhibits considerable global minimum within 20 ns interval while ligands retained in the catalytic pocket of the mh-Tyr during the 100 ns interval by comparison to the positive inhibitor (Fig

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These data support pathophysiology of MSL hypothesis 1 above for the development of MSL but also support hypothesis 2 in that alcohol may cause widespread damage to mitochondria

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