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GLP-1 can induce the expression of FNDC5 in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of WAT to BAT and enhancing energy metabolism [85]

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This tripeptide, composed of three amino acidscysteine, glycine, and glutamic acidis naturally produced in every cell of your body, with the highest concentrations found in the liver