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The most commonly reported adverse effects were mild to moderate headache and gastrointestinal symptoms including diarrhea, flatulence, nausea, and increased appetite

Milk fat globule-EGF factor 8 (MFG-E8) is an antifibrotic glycoprotein in MSC secretomes that strongly inhibits TGF signaling and reduces ECM deposition and liver fibrosis in mice [18]

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Safety: This reclassification acknowledges the safety data presented in recent years and ensures that patients can access these tools through regulated, high-quality pharmaceutical channels rather than unregulated sources