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Common side effects of semaglutide at injection site According to John La Puma, MD, a board-certified internist, weight management expert, best-selling author of REFUEL, and founder of The Ozempic Blueprint: A Simple Guide to Boost GLP-1 Naturally of Santa Barbara, California, common side effects of semaglutide at the injection site include the following: Temporary burning Itching Redness Minor bruising or swelling (if a blood vessel is nicked during injection) Rare semaglutide injection site reactions In rare instances, Dr