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SGLT2 side effects Some common side effects of SGLT2 inhibitors may include: Urinary tract infections Certain genital infections in people with vaginas, including bacterial vaginitis, vulvovaginitis, and candidiasis (yeast infection) Nausea Increased urination Constipation These drugs can also increase the risk of blood vessel (vascular) problems in the legs, which, in extreme cases, could lead to amputation

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