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Oral Semaglutide and Cardiovascular Outcomes in Patients With Type 2 Diabetes (PIONEER 6) New England Journal of Medicine Demonstrated cardiovascular safety of oral semaglutide 14 mg daily versus placebo in 3,183 high-risk T2DM patients, with trend toward all-cause mortality reduction

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Commercially available enzyme-linked immunosorbent assays (ELISA) were used for determination of total GLP-1 (736 and 936) (ALPCO, Salem, NH), GLP-2 (133 and 333) (Merck Millipore, Burlington, MA) and DPP4 (R&D Systems, Minneapolis, MN) plasma concentrations and were carried out according to the manufacturers instructions

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