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182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)

The media was changed to the same media but with charcoal-stripped fetal bovine serum (FBS), 24 h before and during the treatments with either 1100 nM of the steroids (Sigma) for 24 h, or anti-inflammatory cytokines: IL-4, IL-10, or IL-13 (1-100 ng/ml for 24 h), alone or before addition of E2

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Fipronil induced oxidative stress in kidney and brain of mice: protective effect of vitamin E and vitamin C