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The effects of this increase vary depending on the level and location of ROS generation, the efficiency of antioxidant systems, the availability of plastic and energy resources, and the cellular targets involved (Sies 1997

NAFLD has become increasingly common in the UK, affecting approximately one in three adults, often associated with obesity, type 2 diabetes, and metabolic syndrome

doi: 10.1016/j.omto.2017.05.005 108 PawlikTMNakamuraHMullenJTKasuyaHYoonSSChandrasekharSet al

These lipid hydroperoxides are unstable and can decompose into secondary oxidative products, such as aldehydes, alkanes, and ketones, with malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) being notable for their cytotoxic and mutagenic effects [51]