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68 With a plethora of research for the mechanism of action of metformin, currently, the exact mechanism still stands controversial as the previous research studies conducted on preclinical models, in vitro and cell line models used a very high concentration (~milli-Moles) of metformin as compared to the therapeutic concentration (~micro-Moles) used in humans

Conversely, GLP-1 agonist therapy reduced body weight more in children with obesity (-2.74 kg) than in children with T2DM (-0.97 kg) [25]

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These drugs help regulate appetite and promote weight loss, making them valuable tools in metabolic care