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Once inside, it inhibits NF-kB and MAPK cascades, preventing production of pro-inflammatory cytokines at the transcriptional level

There is a lack of long-term effects data, including concerns about abnormal cell growth and the need for ongoing evaluation and monitoring

A 2025 pilot study infused up to 20 mg of BPC157 intravenously in 2 healthy adults and reported no adverse effects and no abnormal changes in heart, liver, kidney, thyroid, or bloodglucose markers

Committee members nevertheless voted to recommend inclusion after considering available data as well as testimony from physicians, compounders and patients who argued that the peptide fulfills an unmet clinical need