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Abstract Brain iron dyshomeostasis plays a critical role in the pathology of multiple central nervous system (CNS) disorders, including neurodegenerative and neuropsychiatric diseases

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AA: arachidonic acid ACC1: acetyl-CoA carboxylase alpha ACSF2: andacyl-CoA synthetase family member 2 ACSL4: acyl-CoA synthetase long-chain family member 4 AOA: aminooxyacetic acid AKF: acute kidney failure ATP5G3: ATP synthase F0 complex subunit C3 BSO: buthionine sulfoximine BHT: butylated hydroxytoluene CARS: cysteinyl-tRNA synthetase CHAC1: cation transport regulator-like protein 1 COX-2: cyclooxygenase-2 CS: citrate synthase CSSG: cysteine-glutathione disulfide DAMP: damage-associated molecular pattern molecule DMT1: divalent metal transporter 1 ER: endoplasmic reticulum Fe3+: ferric iron Fe2+: ferrous iron FIN: ferroptosis-inducing agents FLT-3: fms-like tyrosine kinase 3 FTH1: ferritin heavy chain 1 FTL: ferritin light chain GPX4: glutathione peroxidase 4 GSH: glutathione HMGB1: high mobility group box 1 HD: Huntingtons disease HETE: hydroxyeicosatetraenoic acid HO-1: heme oxygenase-1 HPETE: hydroperoxyeicosatetraenoic acid HSF-1: heat shock factor-1 HSPB1: heat shock protein beta-1 HCC: hepatocellular carcinoma IREB2: iron-responsive element-binding protein 2 JNK: c-Jun NH 2 -terminal kinase Keap1: Kelch-like ECH-associated protein 1 LOX: lipoxygenases LPCAT3: lysophosphatidylcholine acyltransferase 3 MAPK: mitogen-activated protein kinase MDM2: murine double minute-2 MEFs: mouse embryonic fibroblasts NADPH: nicotinamide adenine dinucleotide phosphate NAPQI: N -acetyl- p -benzoquinone imine NOX: NADPH oxidase NRF2: nuclear factor erythroid 2-related factor 2 OLs: oligodendrocytes PDAC: pancreatic ductal adenocarcinoma PGSK: phen green SK PKC: protein kinase C PPP: pentose phosphate pathway PTGS: prostaglandin-endoperoxide synthase PUFAs: polyunsaturated fatty acids PVL: periventricular leukomalacia RCD: regulated cell death ROS: reactive oxygen species RPL8: ribosomal protein L8 RSLs: Ras-selective lethal small molecules SCP2: sterol carrier protein 2 TFR1: transferrin receptor 1 TTC35: tetratricopeptide repeat domain 35 VDAC: mitochondrial voltage-dependent anion channel

This includes: Diluting the Vitamin B12 in a compatible IV solution Administering the infusion over a specified period, typically 30 minutes to an hour Monitoring the patient for any adverse reactions during and after the infusion By carefully considering these factors and following established guidelines, healthcare providers can optimize IV Vitamin B12 therapy for their patients

Diabetes, particularly when blood sugar is poorly controlled, causes dehydration-related dry mouth