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Additionally, the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and fibroblast growth factor 21 receptor (FG21R) also significantly influence these metabolic processes

335,336 The expression of iNOS is primarily activated by the NF-B pathway, which is activated and translocated to the nucleus upon inflammatory stimulation (such as bacterial endotoxins or pro-inflammatory cytokines), thus increasing the transcription and expression of iNOS

So far, berberine can be administered only via the oral route

With improved blood sugar control, individuals experience fewer diabetes-related symptoms and complications, leading to a better overall quality of life