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It has to be noted however that gain of function may also develop in parallel with loss of function, with reactive astrocytes for example losing their ability to clear glutamate in the context of motor neurone diseases

Seasonal variation in thyroid function in over 7,000 healthy subjects in an Iodine-sufficient area and literature review

Oral small-molecule GLP-1 drugs represent the next wave of innovation because they: Offer easier administration than injectables Could reduce manufacturing complexity May support broader patient adoption Pfizers move signals its intent to strengthen its metabolic-disease portfolio after earlier setbacks in its obesity pipeline