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Avoid sudden dose increases

The induction of GADD45A expression and G1 arrest by fucoxanthin was positively regulated by inhibiting p38 MAPK pathway in HepG2 cells and negatively regulated by inhibiting SAPK/JNK pathway in DU145 cells [29]

Oxidative stress parameters, induction of lipid peroxidation, and ATPase activity in the liver and kidney of Oreochromis niloticus exposed to lead and mixtures of lead and zinc