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Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice

We did not observe any form of seizure like activity in any of the animals where MGF was over-expressed

Mast cell-mediated local passive allergic reactions in mice were assessed following treatment with 10 mg/kg or 20 mg/kg pterostilbene [209]

In an open-label, phase 3, multicenter study involving 11 children aged 25 years with biallelic POMC, PCSK1, or LEPR variants, or genetically confirmed BardetBiedl syndrome (BBS), 83% achieved a 0.2-point reduction in BMI Z score over 52 weeks, with a mean BMI reduction of 18% observed overall (26% in the POMC/LEPR group and 10% in the BBS group) [45]