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Hirotsu 2012
Anti-Inflammatory and Cytokine Modulation Research: Across multiple rat inflammatory models (carrageenan-induced paw edema, colitis, arthritis), the blend synergistically reduced pro-inflammatory cytokines (TNF-, IL-6, IL-1), inhibited leukocyte infiltration, and accelerated resolution of inflammation while minimizing fibrosis and scar formation
Originally developed as a tanning agent (acting via MC1R receptors), it also binds to melanocortin receptors in the brain (particularly MC3R and MC4R) that influence sexual function
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