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GSSG accumulation induced cellular protein S -glutathionylation Post-translational protein S -glutathionylation occurs via the reversible addition of a proximal donor of glutathione to thiolate anions of cysteines in target proteins

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But injectable glutathione sits in a complicated regulatory space

doi: 10.3389/fnut.2026.1761992 Received 06 December 2025 Revised 19 January 2026 Accepted 23 January 2026 Published 12 February 2026 Volume 13 - 2026 Edited by Philippe Grard, Institut National de recherche pour lagriculture, lalimentation et lenvironnement (INRAE), France Reviewed by Kristal Potter, Larkin University, United States Kusumakshi Nayak, MAHE, India Updates Copyright 2026 Ray and Shankaran