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Pillai O, Panchagnula R

By stimulating both pathways simultaneously, tirzepatide amplifies: Incretin signal Enhances beta cell function Lowers fasting and postprandial blood glucose levels Body weight Why a Dual Agonist Was Developed: Diabetes, Obesity, and Incretin Limits Type 2 diabetes is characterized by: Impaired insulin secretion Insulin resistance Altered gut hormone signaling Native incretins are rapidly degraded, and their insulin-stimulating effects are blunted in people with diabetes

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