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A meta-analysis of 18 clinical trials involving 1,883 women with poor ovarian response undergoing IVF or intracytoplasmic sperm injection found supplementing with 75 mg DHEA daily for two to four months reduced the risk of miscarriage by 50%, increased the pregnancy rate by 53%, and increased successful births by 87%

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However, in an in vivo study performed in diabetic rats with brain ischemia, the anti-oxidant effects of liraglutide treatment (i.e., increased SOD and reduced myeloperoxidase levels) were mediated by activation of the mitochondrial ATP-sensitive potassium channel composed of sulfonylurea receptor 1 (SUR1) and the K + -selective inward rectifier Kir6.2 [90]