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PMID: 203 PotnisKCRossJSAnejaSGrossCPRichmanIB

Most of the these are repurposed (95%), so the number of available marketed products is not a reflection of targeted product development

p53 tumour-suppressor caution Because FOXO4-DRI intervenes in the p53 pathway, which is critical for tumour suppression, there is theoretical concern that interfering with p53 dynamics might carry oncogenic risk

Conclusions In this chapter, we have discussed how NRF2 controls the antioxidant response and reprograms cellular metabolism to support antioxidant function, as well as the role of these pathways in tumorigenesis, stem cell function, and aging