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The antidote is drafting claims that incorporate non-obvious release kinetics data, specific polymer ratios backed by in vivo PK studies, or novel excipient combinations with unexpected bioavailability outcomes

As per Bradford Hills criteria 41 , the biological plausibility through GLP-1R expression in the nervous system and temporal consistency in time-to-onset analysis support potential causality, but confounding factors inherent to spontaneous reporting systems preclude definitive conclusions

The released Fe 3+ exhausted intracellular GSH via Fenton reaction, boosting ROS production by TCPP-mediated PDT (Figures 2B, C)