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Interestingly, taxonomic groups Clostridia and Clostridiales increased consistently, indicating that CB0313.1 promoted the establishment of a protective microbiota enriched in Clostridiales (from 32.95% in HF diabetic control to 56.53% in CB0313.1-treated mice, p = 0.039), which were reported to resist inflammation and involved in type 2 immunity such as type 1 diabetes 21

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