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10.3390/ijms26010303 494 RajasekarK.MuntahaS

Proteolytic knockdown of GPX1 is highly consistent with previously documented effects of recombinant SARS-CoV M pro in transfected cells, including increased reactive oxygen species and NF-B activation

It also stimulates the overexpression of the transient receptor potential melastatin 2 (TRPM2) ion channels, triggering macrophage activation, leading to a systemic immune response

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