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J Neurochem 97(suppl 1):1115 Rao KV, Qureshi IA (1999) Reduction in the MK-801 binding sites of the NMDA sub-type of glutamate receptor in a mouse model of congenital hyperammonemia: prevention by acetyl-L-carnitine

Animals were single-housed after the procedure and allowed to recover for 4 weeks prior to treatment start

Knowing this arc is useful for two reasons, because it tells you that a rough day right after a dose increase is expected rather than a signal that the drug is wrong for you, and it tells you when to be most disciplined about the levers below, since the two or three days after each new dose are when meal size and composition matter most

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