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Given the APCs location on the ventrolateral cortical surface, near several pain-related regionsincluding the lateral nucleus accumbens (LatNAc) 31,32 , ventral pallidum (VP) 33 , anterior insular cortex (AIC) 34 , and reticular thalamic nucleus (TRN) 35 , which are associated with pain and some of which project to the MD 35,36 , we carefully assessed potential viral spread beyond the APC

This cytokine shift, which enhances antiviral and antitumor immune responses, which are critical for the elderly to fight age-associated diseases, is linked to an increase in NK cell numbers, potentially explaining the enhanced IFN- production [212]