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While binding to GLP-1 causes pancreatic cells to secrete insulin, in the brain, GLP-1 activates neurons in the hypothalamus, resulting in a feeling of satiation, or fullness

The trial also identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients a safety signal that doesn't appear in the cagrilintide literature

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