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Histone modifications Histones are core proteins of chromatin, and their chemical modifications (e.g., acetylation, methylation, and phosphorylation) regulate chromatin structure and gene activation or silencing

BMI of 30 or higher BMI of 27 or higher with a weight-related condition such as hypertension, type 2 diabetes, or high cholesterol Difficulty losing weight despite consistent diet and exercise Weight change associated with metabolic or hormonal factors A history of weight cycling, meaning repeated loss and regain A preference for a structured, clinically supervised program with in-person follow-up Is This Treatment Right for You

Eves-Van Den Akker S, Lilley CJ, Yusup HB, Jones JT, Urwin PE

Canal-Martn, A