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The 25(OH)DVDBP complex is filtered by renal glomeruli and taken up into proximal tubule cells via endocytosis mediated by the megalin/cubilin receptor complex

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In addition, the involvement of the SIRT1/PGC-1 pathway in the protective effects of antioxidants against DN is also evident in studies involving nicotinamide mononucleotide (NMN)