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doi: 10.1136/lupus-2018-000291

Will they have to be taken for the remaining 50-plus years of someone's life

Remarkably, the simple parsimonious model of a negative feedback in the GPCR signaling pathway captures the key features that we observed experimentally (Fig 2): An on step of the diacetyl stimulus resulted in a single calcium pulse, which decayed to baseline levels even though the stimulus remained constantly present (Fig 2A)