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Previously, it was believed that VC occurred passively, involving the deposition of calcium and phosphate as hydroxyapatite in the arterial wall

It should have a defensible medical purpose, an appropriate prescriber, a qualified sterile-compounding source and informed consideration of the evidence and risks

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The directional migration is mediated by secreted chemokines that form a concentration gradient towards the site of inflammation (Koopmann and Krangel, 1997)