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Lee noted, "Acute pancreatitis can usually be resolved if detected early and treated with fasting and fluid therapy." However, he warned, "If left untreated, it can lead to fatal complications like necrotizing pancreatitis, where pancreatic cells die, or multiple organ failure, as well as secondary conditions like chronic pancreatitis and diabetes, so a swift response is crucial." However, even when synthesizing the latest research, there is still insufficient evidence that the entire class of GLP-1 drugs increases the risk of pancreatitis

That data just doesnt exist for most of these peptides, Brunner said

For now, retatrutide remains in clinical trials with uncertain approval timeline