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Enzymes such as urease and catalase can lose up to 50% of their potency after shaking, fibrinogen clotting activity is decreased after shear stress, and recombinant IL-2 and recombinant interferon activity is substantially affected by aggregation from shaking and shearing (2)

The only symptoms persisting in more than 2% of participants are dry mouth, sleeplessness, and constipation

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Second, the therapeutic effect of LNPG was shown both in vivo and ex vivo , when it was delivered to endothelial cells lacking a glycocalyx (137)