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however, since both receptors share a high degree of structural and functional homology, the IGF1R can bind insulin and the IR can bind the IGFs with reduced affinity

However, glucose is the most potent secretagogue for insulin secretion as it induces robust insulin secretion within a few minutes of the onset of the stimulus and the stimulatory effect lasts as long as the plasma glucose is elevated

Split doses if necessary

In addition, cell lines expressing CTR and AMY receptors from multiple species including rat, mouse, monkey and dog were constructed to meet the requirements for target selectivity and species-specific pharmacological assessment