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Jones, Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

What Clinical Evidence Shows About GLP-1s and Fetal Development Preclinical studies in animals exposed to semaglutide at doses higher than therapeutic human levels revealed delays in fetal skeletal development and changes in cardiac morphology

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There is also evidence for mechanisms involving a reduction of neuroinflammation, an increase in synaptic functioning, as well as the restoration of brain pathways of insulin signaling that may lead to improved memory formation and therefore a positive effect in Alzheimers disease and Parkinsons disease 34