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Clinical Evidence: Head-to-Head PT-141 Clinical Data PT-141 has the stronger regulatory evidence: FDA-approved as bremelanotide for HSDD in premenopausal women (2019) Phase III trials (RECONNECT) demonstrated statistically significant improvement in sexual desire and reduction in distress Efficacy shown in both male and female sexual dysfunction studies Well-established safety profile across large clinical trials Dose-limiting side effect: nausea (40%+ incidence at approved dose) Kisspeptin Clinical Data Kisspeptin has compelling but earlier-stage evidence: IVF oocyte maturation: Successfully used as an alternative to hCG in multiple clinical trials, with zero OHSS cases (Jayasena et al., 2014

SB: Data curation, Validation, Writing review & editing, Investigation, Writing original draft, Visualization