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Literature search was conducted on PubMed, Scopus, Web of Science, and Embase using a combination of the keywords gut microbiota, gut microbiome, gut-brain axis, gut-kidney axis, gut-brain-kidney axis, chronic kidney disease, dysbiosis, therapy, metabolites, and neuroinflammation. Relevant studies were selected and synthesized in this narrative review

The growing number of obese individuals due to several chronic disorders, changing lifestyle habits, rapid urbanization and digitalization fostering sedentary lifestyles