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If you have pernicious anaemia, antibodies are formed against your intrinsic factor, or against the cells in your stomach which make intrinsic factor

The Lee 2016 work adds VEGF upregulation and TGF-beta-1 reduction as supporting mechanisms

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In the few individuals who did have preexisting cross-reactive antibodies, these often targeted the S2 region of spike that is more conserved across coronaviruses but that predominantly induces nonneutralizing antibodies [72, 73]