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The impact we are seeing in OA might be real, but we have to define it more clearly. Although no data are conclusive yet, preclinical studies have shown that GLP-1 receptor agonists can inhibit the NF-kB pathway, a key pathway involved in inflammation and cartilage destruction, according to Lane

Arch Biochem Biophys 640:4752 Ashok A et al (2022) Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: role of nanoparticle-based drug delivery systems in clinical translation

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Coptisine attenuates diabetes-associated endothelial dysfunction through inhibition of endoplasmic reticulum stress and oxidative stress