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Given that immune cell accumulation plays a vital role in eye diseases pathogenesis, previous researchers have also studied the effect of GLP-1RAs on macrophages and discovered that it could reduce macrophage infiltration in addition to altering macrophage phenotypes in multiple sclerosis and nephropathy (Chiou et al., 2019

In agreement with this notion, we found that expression of Glp-1r concentrated in specific neuronal populations, which include two GABAergic neuronal clusters (C35 GABA3 and C35 GABA4) and one glutamatergic neuronal cluster (C35 Glut 8) (Fig